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October 1962

Synthetic Estrogens in Treatment of Atherosclerosis: A Study of Prostatic Cancer Patients

Author Affiliations


From the Institute of Pathology, Rhode Island Hospital.

Arch Intern Med. 1962;110(4):467-471. doi:10.1001/archinte.1962.03620220059010

Prostatic cancer patients were studied from the following aspects: (1) periodic lipid determinations, (2) gross and microscopic study of coronary arteries and aortae in a small number of autopsied cases, (3) retrospective review of 100 autopsy records of prostatic cancer patients, and (4) screening tests of blood coagulation in selected cases.

Except for serum lipid changes as reported by many investigators1,2 no unequivocal effect on arteries or blood coagulation was demonstrated which could be ascribed to estrogen therapy.

Materials and Methods  A. Serum lipids3-6 were determined in a group of 64 presumably healthy male subjects from 60-90 years of age actively employed in the hospital (Table). In 25 subjects the "individual biologic variation" was determined as the standard deviation of the mean obtained by 4 lipid determinations (in the same individual) several weeks to months apart; the average value multiplied by 37 was considered an individual's biologic