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October 1962

Coccidioidomycosis Complicating Hodgkin's Disease: With a Note on Furaltadone-Induced Neuropathy

Author Affiliations


Chief Resident, Department of Medicine, William Beaumont General Hospital; presently Chief, Radioisotope Section, Fitzsimons General Hospital, Denver (Dr. DeNardo); Chief, Hematology Service, William Beaumont General Hospital (Dr. Daniell); Chief, Pathology Service, William Beaumont General Hospital (Dr. Child); Chief, Gastroenterology Service, William Beaumont General Hospital (Dr. Buchanan).

Arch Intern Med. 1962;110(4):476-480. doi:10.1001/archinte.1962.03620220068012

Introduction  Disseminated coccidioidomycosis complicating Hodgkin's disease has not yet been recognized despite the common occurrence of both diseases.We have recently observed a patient in whom the signs and symptoms of Coccidioides were attributed erroneously to the lymphoma. Appropriate therapy for the lymphoma may have contributed to the dissemination of the fungus.

Report of a Case  In April, 1958, the patient, a 25-year-old white male, noted several nodules in the right neck, which enlarged over the ensuing 3 months. In August, 1958, he sought medical care because of weakness and numbness of the left arm precipitated by lying on that arm during sleep. Physical examination revealed firm, nontender right supraclavicular lymphadenopathy. No other abnormalities were found. Complete blood cell count, urinalysis, and chest roentgenogram were normal. Pathologic examination of a cervical lymph node biopsy revealed many Reed-Sternberg cells and eosinophils and was interpreted as Hodgkin's disease, paragranuloma type. The patient

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