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October 1962

Renal Failure and Disseminated Candidiasis

Author Affiliations


Present address: Department of Medicine, New York Hospital—Cornell Medical Center, New York.; The Pathologic Anatomy Department, National Cancer Institute, National Institutes of Health.

Arch Intern Med. 1962;110(4):526-534. doi:10.1001/archinte.1962.03620220118020

Candida albicans and related species are ubiquitous inhabitants of the normal human body. These fungi can often be cultured from skin, genitalia, oral cavity, and intestinal and respiratory tracts.1-3

Although localized infections of oral cavity, vagina, rectum, skin, nails, lungs, endocardium, and meninges have been frequently reported4-14 and systemic infections in debilitated infants are not uncommon,15-18 the clinical features of disseminated disease in adults have only recently been described.19-22 Numerous communications citing both clinical and experimental observations have attempted to define the role of antibiotics, steroids, depressed host resistance, and chemotherapeutic agents as factors which might favor dissemination of Candida organisms from either natural habitats or from areas of localized infection.15,18,23-26

In the patient herein reported, acute renal failure was the primary manifestation of disseminated candidiasis.

Histological studies of tissues from cases of fatal systemic human moniliasis have disclosed the common occurrence of multiple renal

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