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November 1962

Studies in Experimental Amyloidosis: III. The Effect of Cortisone Administration on the Incidence of Casein-Induced Amyloidosis in the Rabbit

Author Affiliations


Associate Professor of Medicine, Boston University School of Medicine (Dr. Cohen); Professor of Medicine, Buffalo University School of Medicine (Dr. Calkins); Research Fellow in Microbiology, Washington University, St. Louis (Dr. Mullinax).; From the Medical Services, Massachusetts General Hospital; The Department of Medicine, Harvard Medical School, and The Robert Dawson Evans Department of Clinical Research, Massachusetts Memorial Hospitals, and Department of Medicine, Boston University School of Medicine.

Arch Intern Med. 1962;110(5):569-573. doi:10.1001/archinte.1962.03620230015004

Amyloidosis continues to maintain its reputation as a disease of unknown etiology and, in nearly all instances, progressive course. In an effort to gain more understanding of the nature of this disease, investigators have attempted to define the influence on its course of a variety of external variables. This list includes nitrogen mustards and x-ray therapy (which are said to accentuate the disease) and splenectomy, which has been reported to lessen its severity.1-6

One of the variables whose influence has practical as well as theoretical importance is the administration of adrenal cortical steroids. Questions concerning possible influence of steroid therapy on the course of amyloidosis are often raised by clinicians, especially with regard to patients with rheumatoid arthritis and nephrosis, 2 conditions which are frequently associated with amyloidosis, in which corticoid therapy may be considered.

Unfortunately, the reported effects of adrenal cortical therapy in human and experimental amyloidosis have

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