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November 1962

Paper Electrophoresis of Serum Proteins: Paper Electrophoresis in Some Hematological Diseases and in Disseminated Lupus Erythematosus

Author Affiliations


Associate Professor (Dr. Grigsby, Dr. Bullock); Assistant Resident (Dr. Fuertes), College of Medicine, Howard University.

Arch Intern Med. 1962;110(5):619-627. doi:10.1001/archinte.1962.03620230065011

Electrophoresis is among the most important modern physiochemical methods; however, the important early experiments in this field were performed in the first years of the 19th century. Reuss,1 in 1807, noted the electro-osmosis of water through clay by the passage of electric current. Porrett,2 in 1876, observed the migration of water through bladder under the influence of galvanic current and also extended the experiments to filter paper impregnated with egg albumen. Electrophoresis has been used in the study of a number of medical problems and has produced interesting and important results.

This study was undertaken in an attempt to determine what changes in the serum proteins occurred in hematological diseases and in disseminated lupus erythematosus. We were particularly concerned with effects upon the γ-globulin and whether this knowledge would be applicable in the over-all care of these patients. We had noted, as others, that many patients with these