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November 1962

Antibody Distribution Against Nonenteropathic E. Coli: Relation to Age, Sex, and Breast Feeding

Author Affiliations


From the Departments of Preventive Medicine and Medicine, University of Virginia School of Medicine.; Markle Scholar in Medical Science.

Arch Intern Med. 1962;110(5):676-686. doi:10.1001/archinte.1962.03620230122017

Escherichia coli have been the subject of a vast number of studies since first characterized more than 75 years ago. They constitute the predominant flora of the colon of many animal species, including man, and have been shown to be of great importance in nutrition, in the metabolism of drugs, in certain diarrheal diseases, and in infections of the urinary tract. Conflicting evidence has been presented concerning the role their products play in the pathogenesis of irreversible shock.1-3 Under ordinary conditions, these organisms do not appear to disturb the host; in certain circumstances, however, such as during the neonatal period, with hypogammaglobulinemia, localized obstruction, excessive irradiation, adrenal cortical steroid therapy, and neoplasia, they may become invasive and threaten life.4 Certain strains which possess hemolytic activity, skin-necrotizing power,5 and resistance to the bactericidal activity of serum6,7 at times appear to be more invasive than others. In general,

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