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January 1963

Primary Hepatoma with Apparent Successful Surgical Resection

Author Affiliations


From the Division of Hematology (Dr. Anbe and Dr. Monto), Department of Surgery (Dr. Smith), and Department of Laboratories (Dr. Patton), the Henry Ford Hospital.

Arch Intern Med. 1963;111(1):10-15. doi:10.1001/archinte.1963.03620250014003

The diagnosis of primary neoplasm of the liver, whether it is a Kupffer-cell sarcoma,1 liver-cell carcinoma, bile duct carcinoma, or a mixture of liver-cell and bile duct carcinoma, has almost always been associated with a dire prognosis. Several characteristics of hepatomas with predisposition to an early death are: (1) difficulty in making an early diagnosis, (2) associated severe liver disease, and (3) surgical limitations in accomplishing complete extirpation. The patient usually presents with an abdominal mass, abdominal pain, or weight loss, icterus, and ascites.2-4 By the time these usual symptoms or less frequently observed signs (e.g., of an acute abdomen with hemorrhage) are manifest, the neoplasm has commonly undergone metastasis especially to the thoracic and abdominal organs or in some cases to bone.5

Generally, hepatomas are multiple making hepatectomy as a therapeutic measure impractical; however, this is not necessarily true with solitary hepatomas. Solitary hepatoma constitutes only

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