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January 1963

Nephritis and Lung Hemorrhage: Goodpasture's Syndrome

Author Affiliations


Resident in Internal Medicine (Dr. DeGowin); Resident in Pathology (Dr. Oda); Resident in Surgery (Dr. Evans).

Arch Intern Med. 1963;111(1):16-22. doi:10.1001/archinte.1963.03620250020004

Patients dying with pulmonary hemorrhage and glomerulonephritis recently have excited interest in Goodpasture's syndrome. In 1919, while trying to relate pulmonary lesions in influenza to its etiology, Goodpasture reported the case of an 18-year-old boy who entered the hospital 1 month after recovering from a "typical" attack of influenza with cough, hemoptysis and chest pain.1 Mild fever, anemia, leukocytosis, and albuminuria were noted before his death.

Necropsy disclosed consolidation of the lungs with hemorrhage from necrotic alveolar capillaries, subcapsular and cortical renal hemorrhages, and a "glomerular nephropathy" with cellular proliferation of the glomerular tufts and red cells in the tubular lumens. One to two millimeter bright red hemorrhages in the wall of the small intestine were described microscopically as focal lesions in the walls of arterioles with fibrinous exudates and few leukocytes.

Stanton and Tange2 urged us to adopt the name "Goodpasture's syndrome" to denote the combination of

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