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January 1963

Adult Celiac Disease: Treatment with a Gluten-Free Diet: Serial Metabolic and Pathologic Studies in Six Patients

Author Affiliations


Fellow in Medicine (Dr. Bayless); Assistant Professor of Pathology, The Johns Hopkins University, School of Medicine (Dr. Yardley); Associate Professor of Medicine, John and Mary R. Markle Scholar in Medical Science, The Johns Hopkins University, School of Medicine (Dr. Hendrix).; Present address of Dr. Bayless: Tropical Research Medical Laboratory, APO 851, New York. The Departments of Medicine and Pathology, The Johns Hopkins University, School of Medicine and Hospital.

Arch Intern Med. 1963;111(1):83-92. doi:10.1001/archinte.1963.03620250087012

Adult celiac disease (nontropical sprue or idiopathic steatorrhea) is manifested clinically by steatorrhea and deficiencies produced by intestinal malabsorption. Diarrhea and weight loss are often prominent symptoms. Celiac disease in childhood is probably the same disorder.

In 1950, Dicke1 reported clinical improvement in childhood celiac disease when wheat and rye flour were removed from the diet. Further studies2 have shown that wheat, rye, barley, and oat gluten contain an offending agent. Subsequently, the efficacy of the gluten-free diet in the treatment of celiac disease has been confirmed in adults3-5 as well as in children.6,7 Clinical remissions are reported in 80%8 to 93% of adult patients.9 Some patients, although clinically improved, have residual evidence of abnormal intestinal function. Green et al.10 in 1959 described 10 patients in clinical remission on a gluten-free diet, who had persistent steatorrhea by chemical determination.

This is a report

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