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February 1963

Hepatic Uptake Defect in Patients with "Gilbert's Disease"

Arch Intern Med. 1963;111(2):214-218. doi:10.1001/archinte.1963.03620260074013

Radioactive-iodide-labeled iodipamide (R.I.I.) is a simple, practical, and useful liver function test. In general it gives the same information that is obtained by sulfobromophthalein (SBP) retention studies.1 Adequate collimation is of paramount importance when the hepatic uptake is measured after the intravenous injection of R.I.I.

Method  After an overnight fast, the patients were placed in the supine position and 2 scintillation detectors were positioned: one over the heart and the second over the liver. The hepatic monitor was placed at the midclavicular line approximately 3 cm. cephalad to the lower costal margin. Approximately 3 cm. clearance was permitted between the probe and the skin surface. The probe was a Nuclear-Chicago Model DS-5 Serial 1519 to which no additional columniation was added. An intravenous dose of 15μc R.I.I. was administered.The R.I.I. test is performed as described by McLaren, Galambos, and Weens.1 The hepatic uptake was calculated directly from

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