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February 1963

Acute Syphilitic Nephrosis: Case Report

Author Affiliations


Resident in Medicine, Hospital of St. Raphael (Dr. McDonald); Attending in Medicine, Chief of Renal Section, Hospital of St. Raphael, formerly Assistant Clinical Professor, University of Cincinnati (Dr. Barile).

Arch Intern Med. 1963;111(2):228-233. doi:10.1001/archinte.1963.03620260088016

"The manifestations of a genuine syphilitic nephrosis or nephritis are so infrequent that even those who specialize in renal diseases may be confused by their occurrence."1 In 1935, Herrmann and Marr2 published an excellent review of clinical nephropathies related to syphilis. From that date to the present, there have been only 24 cases of syphilitic nephrosis published in the American literature.3 With this knowledge in mind, we are reporting our recent experience with a case of syphilitic nephrosis in a 25-year-old male.

Report of a Case  On Aug. 29, 1961, a 25-year-old male machinist presented with a 3-day history of facial and abdominal swelling, associated with a "dry" feeling in the epigastric region. Over a 1-week period, he had also noted increasing shortness of breath on exertion and weight gain. He denied venereal disease contact. There was no history of drug ingestion. His past history was noncontributory