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March 1963

Gastric Mucosa in Acute Duodenal Ulcer

Author Affiliations


Yale University School of Medicine, Department of Internal Medicine.

Arch Intern Med. 1963;111(3):363-366. doi:10.1001/archinte.1963.03620270089014

This study was undertaken to determine the status of the gastric mucosa in duodenal ulcer patients during a phase of active symptoms and after a period of treatment and subsidence of symptoms. We were interested in assessing any role of gastritis in the acute symptoms and in determining whether the development of histological alterations in the gastric mucosa was in any way related to subsidence of duodenal ulcer symptoms.

The gastric mucosa of duodenal ulcer patients has been studied in operative and postmortem specimens and, more recently, by means of the vacuum biopsy tube. The gastric mucosa was normal in 19 out of 34 duodenal ulcer patients studied by vacuum biopsy.1 In 97 cases of duodenal ulcer, Wood's tube biopsy revealed normal gastric mucosa in 60.2%, superficial gastritis in 34.7%, and atrophic gastritis in 5.1%.2

Examination of stomachs of duodenal ulcer patients at surgery or postmortem examination usually

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