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April 1963

Renal Vein Thrombosis in Malignant Disease: A Report of a Case Developing the Nephrotic Syndrome

Author Affiliations


From the Service of Oncology, Department of Medicine, Bryn Mawr Hospital.

Arch Intern Med. 1963;111(4):449-451. doi:10.1001/archinte.1963.03620280049007

The occurrence of the nephrotic syndrome secondary to renal amyloidosis has been well documented in medical literature. This may be secondary to various chronic infections, rheumatoid arthritis, carcinoma, leukemia, Hodgkin's disease, multiple myeloma, and familial Mediterranean fever.1 A less common cause of the nephrotic syndrome is bilateral renal vein thrombosis. Because of the rare association of the nephrotic syndrome due to renal vein thrombosis with malignant disease, a new case is presented.

Report of a Case  A 42-year-old white male electrician was admitted to the hospital on June 11, 1958, complaining of a gradual decline in well-being and energy, and progressive swelling of the legs over the previous 3 weeks.He stated that he had been well until December, 1956, when he noticed mild rectal discomfort. He consulted a proctologist, who found a fungating mass 3 cm. in diameter on the anterior surface of the rectum just above the