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April 1963

Anticoagulant Therapy

Arch Intern Med. 1963;111(4):534-535. doi:10.1001/archinte.1963.03620280134037

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Regardless of one's reaction to the current conflict concerning the efficacy of anticoagulants in the treatment of thromboembolic disease, no practicing internist can afford to be unfamiliar with the techniques of anticoagulant therapy and the management of its complications. The reader will find this book to be an excellent guide and reference for this purpose. It is a detailed account of the historical, pharmacological, and clinical facts about anticoagulants. In some places, the material seems almost too detailed and abundant. The inclusion of 52 pages of information about the blood coagulation mechanism and fibrinolysis seems excessive to me.

It is apparent that the author is enthusiastic in the use of oral anticoagulants. Many readers will question the statement that there is a greater tendency to hemorrhage with heparin therapy than with coumarin drugs. I find it difficult to accept the recommendation "any patient with a clear indication for long-term therapy

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