When breast cancer spreads beyond control by surgical or roentgen therapy, regressions can still be produced by the administration of hormones, endocrine ablative procedures, or by chemotherapy. In postmenopausal women estrogens and androgens produce objective regressions as primary hormonal therapy in 20% to 30% of all cases* When such primary therapy ceases to be effective, or if the disease fails to respond to it, secondary hormonal therapy generally produces fewer objective regressions. The purpose of this study is to compare the antitumor efficacy of various secondary hormonal treatments in advanced breast cancer and to attempt to ascertain whether regressions obtained from hypophysectomy are due to the removal of pituitary factors or to hormonal replacement therapy.
All postmenopausal women with objectively progressing disseminated breast cancer previously treated by hormonal therapy under the protocol of the Cooperative Breast Cancer Study Group1 or referred to us after hormonal therapy had been
WITT JA, GARDNER B, GORDAN GS, GRAHAM WP, THOMAS AN. Secondary Hormonal Therapy of Disseminated Breast CancerComparison of Hypophysectomy, Replacement Therapy, Estrogens, and Androgens. Arch Intern Med. 1963;111(5):557–563. doi:10.1001/archinte.1963.03620290023005
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