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May 1963

Unilateral Primary Interstitial Pulmonary Fibrosis: Unknown Etiology

Author Affiliations


Assistant, Department of Otolaryngology, University of Rochester, School of Medicine and Dentistry.

Arch Intern Med. 1963;111(5):612-619. doi:10.1001/archinte.1963.03620290078010

The purpose of this paper is to discuss a case of primary interstitial pulmonary fibrosis limited to one lung. The discussion will revolve around the classification of this particular case, which has no demonstrable etiology. Particular interest is devoted to the Hamman-Rich syndrome and the possibility of an allergic etiology.

A 28-year-old, 5 months' pregnant white female was admitted to Rochester General Hospital. Two years previously she had first noted a chronic cough with morning production of one teaspoon of white sputum. Progressive dyspnea had been noted 4 to 6 months prior to admission, and orthopnea had been present for 2 weeks as had daily hemoptysis of one cup of blood, with coughing and dyspnea. She had been seen in another hospital for these complaints one week before admission, when right basilar pneumonitis and cardiomegalia were diagnosed. Penicillin, tetracycline, and sulfa drugs had been used for the month prior to