This book consists of 27 essays dedicated to Charles Huggins as a tribute from his pupils, colleagues, and friends on his sixtieth birthday. The essayists, a distinguished group who reflect broad backgrounds of capabilities, include three Nobel prize winners. Six contributors are from England, eighteen from the United States and one each from Germany, Sweden, and Chile. The searching and catholic scientific interest of Charles Huggins is mirrored in the broad array of material dealt with in the monograph; this ranges from aphilosophical dissertation by Peyton Rous entitled "The Disagreement Amongst Doctors" to several sophisticated accounts of recent laboratory investigations and four essays dealing with clinical experimentation and observations. The thread of continuity from essay to essay is the personal association of each author with Charles Huggins. It will be the rare reader who will (or can) move with interest and understanding from one presentation to another. On the other