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June 1963

Clinical and Laboratory Studies of Sodium Diphenicillin: I. Activity Against Gram-Positive Cocci in Vitro and Absorption From Gastrointestinal Tract of Human Subjects

Arch Intern Med. 1963;111(6):750-755. doi:10.1001/archinte.1963.03620300070012

Introduction  The purpose of this paper is to present data on the antibacterial activity of a new penicillinase-resistant penicillin and its absorption from the gastrointestinal tract. The drug is sodium diphenicillin (sodium 2-biphenylylpenicillin)1 and is manufactured from penicillanic acid.

Material and Methods  Sodium diphenicillin was supplied to us by Smith Kline & French Laboratories as a white powder and labeled SK&F 12141. It is also known as Ancillin. It is highly soluble in water and is stable in high concentration in aqueous solution for at least ten days at 4 C. Its structural formula has been reported.1

Bacteria Tested.—  The group included 114 strains of mannitol-positive Staphylococcus aureus recovered from various clinical lesions in patients in the Cincinnati General and the Longview State Hospitals. Two strains (Nos. 48 and 49) were methicillin-resistant staphylococci kindly sent us by Dr. Patricia Jevons of the Staphylococcus Reference Laboratory, London, England. Strains