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June 1963

Clinical and Laboratory Studies of Sodium Diphenicillin: I. Activity Against Gram-Positive Cocci in Vitro and Absorption From Gastrointestinal Tract of Human Subjects

Author Affiliations


From the Infectious Disease Laboratory, Department of Medicine, University of Cincinnati College of Medicine and the Cincinnati General Hospital.; Student Research Fellow under USPHS grant E-3523 (Mr. Silverman).

Arch Intern Med. 1963;111(6):750-755. doi:10.1001/archinte.1963.03620300070012

Introduction  The purpose of this paper is to present data on the antibacterial activity of a new penicillinase-resistant penicillin and its absorption from the gastrointestinal tract. The drug is sodium diphenicillin (sodium 2-biphenylylpenicillin)1 and is manufactured from penicillanic acid.

Material and Methods  Sodium diphenicillin was supplied to us by Smith Kline & French Laboratories as a white powder and labeled SK&F 12141. It is also known as Ancillin. It is highly soluble in water and is stable in high concentration in aqueous solution for at least ten days at 4 C. Its structural formula has been reported.1

Bacteria Tested.—  The group included 114 strains of mannitol-positive Staphylococcus aureus recovered from various clinical lesions in patients in the Cincinnati General and the Longview State Hospitals. Two strains (Nos. 48 and 49) were methicillin-resistant staphylococci kindly sent us by Dr. Patricia Jevons of the Staphylococcus Reference Laboratory, London, England. Strains