Myxedema coma may not be as rare as the paucity of literature on this disorder leads one to believe. It is doubtful whether the recent increase in the number of reported cases represents an actual increase in the occurrence of the disease.
In all, 62 cases of myxedema coma have been reported,1 of which 22 patients (36.6%) survived. Undoubtedly many more cases have gone unrecognized or unreported. We know of four other cases in Israel, a small country with a population of 2,200,000, enjoying a warm climate. The first descriptions of hypothermic myxedema coma were published in 18792 and 1888.3 Subsequently there was a wide gap until 1953, when attention was again drawn to it by three publications from England.4-6 Most of the reports have come from Britain.1-16 The first American report was by Levin and Daughaday in 1955.17
We report a case of
KLAJMAN A, BEN-EFRAIM S. Hypothermic Myxedema Coma and Disseminated Lupus Erythematosus: Case Report and Review of the Literature. Arch Intern Med. 1963;111(6):772–777. doi:10.1001/archinte.1963.03620300092015
Best of JAMA Network 2022
Customize your JAMA Network experience by selecting one or more topics from the list below.