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June 1963

Carcinoid Syndrome Originating in Bronchial Adenoma

Author Affiliations


Associate Attending Physician in Medicine and Associate Gastroenterologist (Dr. Frank); Senior Attending Physician, Department of Medicine, and Chief of Gastroenterology (Dr. Lieberthal); Bridgeport Hospital.

Arch Intern Med. 1963;111(6):791-798. doi:10.1001/archinte.1963.03620300111018

Within the last few years the carcinoid syndrome has been thoroughly described, and numerous cases have been reported. Many interesting facets and variations of this syndrome have come to attention. One of these is the carcinoid syndrome originating in pulmonary lesions, usually a bronchial adenoma. The first such case was reported in 1956 by Kincaid-Smith and Brossy.1 Since that time seven other cases have appeared in the literature. It is the purpose of this writing to report the ninth example of this syndrome, to briefly summarize the previously reported patients, and to establish criteria for inclusion in this select group.

Report of a Case  A 67-year-old white married female housewife was first seen on Jan 19, 1960, complaining of abdominal pain, malaise, and weakness of two to three weeks' duration. During the year prior to this first visit, she had suffered flushing attacks associated with a rapid pulse. On

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