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July 1963

Liver Diseases in Ulcerative Colitis: A Review

Author Affiliations


Fellow in Gastroenterology (Dr. Vinnik); Associate Professor of Medicine, Head, Division of Gastroenterology (Dr. Kern).

Department of Medicine, University of Colorado Medical Center.

Arch Intern Med. 1963;112(1):41-49. doi:10.1001/archinte.1963.03860010087009

Introduction  In the past 30 years a number of studies have described the many complications encountered in patients with chronic ulcerative colitis. These studies frequently included large groups of patients, but until recently hepatic disease either was not mentioned or was not prominent as a complication. For example, Bargen, in 1935, noted multiple liver abscesses in two patients as the only complication involving the liver among 1,500 patients with chronic ulcerative colitis.1 In 1938, this same author and others described four patients with "hepatic insufficiency" associated with long-standing ulcerative colitis.2 They observed that they were previously "unable to find a single case of hepatitis and jaundice complicating ulcerative colitis similar..." to these cases. Jackman et al, in 1940, reported that liver abscesses in four patients were the only hepatic lesions in 871 patients with colitis.3 Jankelson, in 1942, reviewed 145 cases of ulcerative colitis and failed to

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