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For six years Dr. Strehler was an important contributor to progress in the study of bioluminescence and of adenosine triphosphate synthesis during photosynthesis. For the last six years he has been chief of the Cell and Comparative Physiology Section of the Gerontology Branch, National Institutes of Health. This book represents his study and formulation of the problems of aging. Ten pages are devoted to the definition, measurement, and determination of direction of flow of time and show rigorous study of a basic factor in aging. Many medical readers, like the reviewer, may skip rather quickly over the next hundred pages containing a review of theoretical approaches, and concentrate on chapters V, VI, and VII, which describe the effects of tissue, cellular, and subcellular aging. They may also hurry through the last 40 pages, again on the theories and on problems for the investigator. But they will find everywhere concise writing