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October 1963

Hypertension, Body Weight, and Coronary Heart Disease

Arch Intern Med. 1963;112(4):550-554. doi:10.1001/archinte.1963.03860040146013

Hypertension was formerly thought to be a direct precursor of coronary heart disease.1 Master concurred with this view in 1939, reversed his opinion in 1953, and in 1961 felt that in men the relationship of the two diseases is not too clear.1,2 Sigler's figures did not indicate that hypertension has any definite casual and prognostic relationship to coronary occluson.3

Keys in 1961 reviewed a few of the more mature epidemiologic studies in progress.4 In some, definite hypertension and relative body weight seemed to be significantly prognostic of subsequent coronary heart disease, but in the group followed by Keys and his associates neither was important.4 Stamler states that hypertension greatly increases the risk of cerebral and coronary atherosclerotic disease and urges practicing physicians to control hypertension and reduce their overweight patients to prevent coronary disease.5

This report is a follow-up study of 527 railway operating employees who were observed to develop