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October 1963

Spontaneous Laceration and Rupture of Esophagus and Stomach: Mallory-Weiss Syndrome, Boerhaave Syndrome, and Their Variants

Author Affiliations


Director of Medicine at Knickerbocker Hospital and Associate Professor of Clinical Medicine at New York University School of Medicine (Dr. Bruno); Associate Attending Surgeon at Knickerbocker Hospital and Instructor of Clinical Surgery at New York University School of Medicine (Dr. Grier); Director of Laboratories at Knickerbocker Hospital and Associate Professor of Pathology at New York Medical College (Dr. Ober).; From the departments of medicine, surgery, and pathology, Knickerbocker Hospital.

Arch Intern Med. 1963;112(4):574-583. doi:10.1001/archinte.1963.03860040170016

Mallory-Weiss Syndrome  In 1929 and 1932 Mallory and Weiss 1,2 reported on 21 patients who presented with hematemesis and massive gastrointestinal hemorrhage following severe vomiting after an alcoholic debauch. Six of these patients died, five from exsanguination and one from rupture of the esophagus with mediastinitis. In the five patients who bled to death autopsy revealed two to four linear, fissurelike lacerations of the mucosa and submucosa of the cardiac portion of the stomach (three cases) extending into the terminal portion of the esophagus (two cases). The lacerations were acute and without fibrous reaction. The patient in whom esophageal rupture occurred was a chronic alcoholic who had had previous episodes of hematemesis, but this symptom was not prominent at his terminal admission. Autopsy revealed an incompletely healed, older laceration of the esophagogastric junction with some fibrosis, and the rupture had occurred through its base in the esophageal portion. The remaining

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