If one injects bovine thrombin intraaortically into dogs, a number of changes take 1-3 place. There is a precipitous fall in the aortic blood pressure which gradually returns to relatively normal levels over a 15to 30-minute period. This is, under proper circumstances, only temporary, and a secondary fall soon begins which terminates fatally within 12 to 24 hours. Autopsy regularly shows a hemorrhagic necrosis of the gastrointestinal mucosa which is typical of canine shock. Blood coagulation changes are interpreted as indicative of an episode of intravascular coagulation. There is a rapid and dramatic fall in level of blood fibrinogen which is marked within 20 minutes but returns to normal or supranormal levels within four to six hours. There is a marked but temporary fall in platelets. Prothrombin time is prolonged. These changes are probably caused by the using up of the blood coagulation factors in an intravascular clotting episode. In
HARDAWAY CRM, JOHNSON CD. Clotting Mechanism in Endotoxin Shock. Arch Intern Med. 1963;112(5):775–782. doi:10.1001/archinte.1963.03860050162020
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