Malaria caused by Plasmodium vivax is a severe illness, yet one which is not ordinarily associated with severe complications or death. For this reason, vivax malaria has long been referred to as "benign tertian malaria."
Transmission of malaria from man to man has been carried out since 1917, to produce "fever therapy" for neurosyphilis and certain chronic psychoses. These induced malaria infections have incidentally provided a vast amount of valuable information concerning the natural history of human malaria. The development of synthetic antimalarial drugs and studies of immunity to malaria have been greatly facilitated by observations on illnesses induced in neuropsychiatric patients and volunteers.
From 1944-1962, malaria has been induced either by the inoculation of parasitized blood or by the bites of infected mosquitos in approximately 2,000 volunteers at the Federal Penitentiary, Atlanta, and the Federal Correctional Institution, Seagoville, Tex, without resulting in death or in a cardiovascular complication
HILL GJ, KNIGHT V, COATNEY GR, LAWLESS DK. Vivax Malaria Complicated by Aphasia and Hemiparesis. Arch Intern Med. 1963;112(6):863–868. doi:10.1001/archinte.1963.03860060101010
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