[Skip to Content]
[Skip to Content Landing]
Article
December 1963

Pulmonary Alveolar Proteinosis With Hematologic Disorders

Arch Intern Med. 1963;112(6):940-946. doi:10.1001/archinte.1963.03860060164018
Abstract

Introduction  Pulmonary alveolar proteinosis is a disorder of obscure and possibly diverse causes. Clinical features frequently observed have been recurrent febrile episodes of "pneumonia," paucity of physical signs on auscultation and percussion, and a disparity between dramatic radiographic findings and relatively little incapacity.1 Several individuals have been asymptomatic at the time of discovery of their disease on routine chest roentgenogram. There may be spontaneous regression of even extensive infiltrates, a circumstance which makes evaluation of therapeutic programs difficult. The duration of the disease may be longer than ten years, or there may be progression to a fatal issue within six months of the apparent onset. In many of the autopsied cases complicating fungal infections have been found.Among the 80-odd cases in the literature are three which were associated with blood dyscrasias. Two additional cases of pulmonary alveolar proteinosis with hematologic disease form the subject of the present report.

First Page Preview View Large
First page PDF preview
First page PDF preview
×