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January 1964

Acute Uric Acid Nephropathy in Leukemia: Report of a Case Treated With Peritoneal Dialysis

Author Affiliations


Arch Intern Med. 1964;113(1):111-114. doi:10.1001/archinte.1964.00280070113018

Introduction  Hyperuricemia and uricosuria are frequently encountered in patients with chronic granulocytic leukemia and the acute leukemias.1 This is believed to be due to an increase in nucleic acid metabolism. Destruction of the leukemic cells and the interference with nucleic acid synthesis following the use of various therapeutic agents (x-ray, alkylating agents, cortisone, and antimetabolites) further augment the production of uric acid.The occurrence of renal failure secondary to intra- and extrarenal crystallization of uric acid with resultant urinary obstruction has been observed during the course of therapy for leukemia.2,3 To reduce the precipitation of uric acid crystals the maintenance of a high urinary output and the alkalinization of the urine have been advocated.We wish to report a case of acute uric acid nephropathy with renal failure which occurred during the treatment of a patient for acute granulocytic leukemia. Peritoneal dialysis was used successfully to reduce azotemia

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