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February 1964

Allergic Granulomatosis: Case Report and Review of the Literature

Author Affiliations


Chief Resident in Medicine (Dr. Varriale); Resident in Medicine (Dr. Minogue); Attending Physician in Medicine (Dr. Alfenito).; From the Department of Medicine, The St. Vincent's Hospital of the City of New York.

Arch Intern Med. 1964;113(2):235-240. doi:10.1001/archinte.1964.00280080071014

Introduction  Allergic granulomatosis was first described in 1951 by Churg and Strauss 1 on the basis of 13 cases mostly derived from autopsy material. Until 1962 when Sokolov et al 2 reported the third case to be diagnosed before death, the disease received scant attention in the literature.3It is the purpose of this communication to present another case of allergic granulomatosis also diagnosed before death, and to discuss its salient clinical and pathologic features and relationship to other similar entities.

Report of Case  A 47-year-old Italian housewife (SVH 065988) was admitted to The St. Vincent's Hospital of the City of New York for the ninth time, on March 29, 1962, complaining of weakness, myalgia, and ankle and facial edema. She gave a seven-year history of severe bronchial asthma requiring almost continuous medication consisting of bronchodilators, expectorants, sedatives, antibiotics, and intermittent adrenocortical steroids. About one year before admission, the