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March 1964

Infectious Mononucleosis Treated With Chloroquine: A Double-Blind Study of 25 Cases

Author Affiliations

From the Internal Medicine Service Section, USAF Hospital, Wright-Patterson Air Force Base, Ohio.

Arch Intern Med. 1964;113(3):412-414. doi:10.1001/archinte.1964.00280090098016

Since the etiology of infectious mononucleosis is unknown, treatment remains symptomatic. Agents such as convalescent serum,1 corticotropin,2 cortisone derivatives,3,4 and γ-globulin5 have been used. Their efficacy has been equivocal and difficult to evaluate due to the lack of suitable controls in most instances and due to the variability of the severity of the disease. In 1960, Gothberg 6 reported dramatic improvement of the symptoms and fever in four patients with infectious mononucleosis when treated with chloroquine phosphate. The purpose of this study is evaluation of chloroquine phosphate in the treatment of infectious mononucleosis utilizing a double-blind technique.

Materials and Methods  All patients admitted to the USAF Hospital, Wright-Patterson Air Force Base, from October, 1961, to September, 1962, with suspected infectious mononucleosis were examined by us and were included in this study. Chloroquine phosphate (Aralen) 250 mg or an identical placebo tablet * was administered from a numbered

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