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March 1964

The Biochemical Diagnosis of Heart Disease.

Arch Intern Med. 1964;113(3):469-470. doi:10.1001/archinte.1964.00280090155036

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This is a curious, widely ranging mixture of clinical art and science with clinical chemistry. The title term "Biochemical" is used apparently to emphasize the biologic nature of the enzymes, principally SGOT, considered in the first 107 pages of text and several appendices. The remaining text concerns other tests and a wide variety of conditions; it includes an informing chapter on fluid and electrolytes in heart disease. Appendices describe methods for SGOT determination, list biochemical tests abnormal in myocardial infarction with appropriate chapter references, give definitions and formulae for fluid-electrolyte terminology, and end with a list of normal values. Much of this last could have been omitted without loss.

The text itself is an exhaustive, well-documented review of an important area in which many of us need authoritative guidance. While concerned mostly with myocardial infarction, it yields a wealth of concise information on clinical and chemical aspects of other

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