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April 1964

Anicteric Hepatitis in Korea: II. Serial Histologic Studies

Arch Intern Med. 1964;113(4):535-542. doi:10.1001/archinte.1964.00280100043008

In the course of a survey of healthy Korean military personnel in an area where viral hepatitis is endemic, about 30 cases of anicteric hepatitis were detected. Their clinical and laboratory manifestations were described in the preceding paper.1 It is the purpose of this report to describe the histologic changes based on three liver biopsies of each of the patients during a three-month period of observation, to describe the histologic evolution during the period of study, and finally to speculate on the relation between anicteric hepatitis and cirrhosis.

Materials and Methods  Thirty-two cases detected among clinically healthy military personnel by serum transaminase tests, as described in the preceding paper,1 were submitted to serial liver biopsy during a period of up to three months' ambulatory hospitalization.First biopsies were performed with a Menghini needle by the intercostal approach 2 two to eight days after the initial SGPT test. A