The association of a leukoencephalitis with malignant lymphoma and chronic lymphatic leukemia was first reported by Astrom et al1 in 1958 and was named "progressive multifocal leukoencephalopathy." By 1961, a total of 11 cases of leukoencephalopathy had been reported.2 The conditions associated with this demyelinating syndrome were Hodgkin's disease (four cases), chronic lymphatic leukemia (three cases), lymphosarcoma (one case), sarcoidosis (one case), pulmonary and renal tuberculosis (one case), and in one case no systemic illness was mentioned.2 Richardson,3 in 1961, reported on 22 cases of progressive multi focal leukoencephalopathy, 20 of which were associated with malignant or granulomatous diseases. Of the remaining two cases, one was associated with coronary artery disease, the other having no known preceding disease. Wiener, Koeze, and Klingon 4 have also noted a demyelinating disease in two patients with Hodgkin's disease.
The association of dermatomyositis with neoplastic diseases is also a well-known
DEEP WD, FRAUMENI JF, TASHIMA CK, McDIVITT R. Leukoencephalopathy And Dermatomyositis In Hodgkin's Disease: A Case Report. Arch Intern Med. 1964;113(5):635–640. doi:10.1001/archinte.1964.00280110015003
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