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May 1964

High Molecular Weight Substances in Human Urine.

Arch Intern Med. 1964;113(5):795. doi:10.1001/archinte.1964.00280110175055

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This is an excellent little volume. Drs. King and Boyce state in the preface that the intent of their book is to present a broad review of what is known about large molecules in normal urine with an extensive but not exhaustive bibliography. This has been admirably accomplished as they have covered such topics as enzymes, high-molecular-weight hormones, mucopolysaccharides, plasma proteins, blood group substances, and methodology and renal functional anatomy.

To many clinicians the title of this book may be a bit frightening, but in actuality it is quite readable and the application to clinical medicine is very apparent. One particularly good chapter is entitled "Physiology of Urinary Macromolecules." In this chapter the authors deal with the fine structure of the glomerulus and the limiting size for substances passing the normal glomerulus, and the problem of normal and pathological proteinuria. Almost every aspect of proteinuria is discussed so that the

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