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June 1964

Glomerular Filtration In Disseminated Breast Cancer

Arch Intern Med. 1964;113(6):837-839. doi:10.1001/archinte.1964.00280120037007

Decreased glomerular filtration rate without azotemia in patients with advanced malignancy has recently been described by Gardner et al.1 This decrease in glomerular filtration rate, as measured by the endogenous creatinine clearance in women with far advanced, progressing malignancy, and its improvement during hormone-induced regressions are the subjects of this report.

Materials and Methods  Nineteen women from the 392 patients seen in the Breast Tumor Clinic of the University of California Medical Center in San Francisco from 1959-1962, who had determination of their creatinine clearance rates before, after, and during regressions of their malignancy, are included in this study.Treatment and the evaluation of each patient's objective response (progression or regression) conformed to the protocols of the Cooperative Breast Cancer Study Group of the Cancer Chemotherapy National Service Center as previously described.2 Regression consisted of (1) measurable decrease in the size of lesions, (2) calcification of osseous lesions,

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