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June 1964

Solitary Myeloma In Chronic Osteomyelitis: Report of Case

Author Affiliations


Fellow in Medicine, Mayo Foundation (Dr. Baitz), and Section of Medicine (Dr. Kyle); Mayo Clinic and Mayo Foundation.

Arch Intern Med. 1964;113(6):872-876. doi:10.1001/archinte.1964.00280120072013

Chronically draining sinuses or fistulae, including sinus tracts of chronic osteomyelitis, are known to undergo malignant changes in some instances.1-3 In the majority of cases, the change is to squamous cell epithelioma, and in only very rare instances are other types of malignancy, such as fibrosarcoma, found.4 This paper describes a case of myeloma developing in sinus tracts of chronic osteomyelitis; only two other cases of this type have been found in the literature.5,6

Report of Case  A 53-year-old white man first was seen at the Mayo Clinic on Sept 1. He had had swelling, tenderness, and drainage from the lower part of the right thigh for the preceding 40 years, and drainage from the medial, and later from the lateral, aspect of the right thigh had been almost constant for the preceding 23 years. There had been several acute exacerbations similar to the one in progress

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