[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
July 1964

Norethynodrel in The Treatment of Factor X Deficiency

Author Affiliations


Assistant Professor of Radiology, Kansas City General Hospital and Medical Center.

Arch Intern Med. 1964;114(1):89-94. doi:10.1001/archinte.1964.03860070135017

The demonstrated improvement of factor X (Prower-Stuart factor) deficiency during pregnancy,1 and the further demonstration by Alexander and Pechet 2 of increased clotting factors during pregnancy, has prompted the use of norethynodrel, a progestational agent, in the control of this clotting disorder.

The case to be reported has been the subject of a previous paper by Brody and Finch 1 wherein the factor X deficiency was first documented and its improvement during pregnancy demonstrated.

Report of a Case  The patient is a 31-year-old married woman who has suffered intermittently from a bleeding tendency since the age of 5. This first became manifest when a tonsillectomy was followed by severe hemorrhage from the operative site. At the age of 7 the patient was hospitalized because of hematuria, epistaxis, and bleeding from the gums. Bleeding stopped after an unknown number of blood transfusions, and she was discharged with a diagnosis of