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July 1964

Chronic Toxoplasmosis Associated With Severe Hemolytic Anemia: Case Report and Electron Microscopic Studies

Author Affiliations


Resident in Pathology (Dr. Kalderon); Instructor in Pathology (Dr. Kikkawa); Assistant Professor in Pathology (Dr. Bernstein).; From the Department of Pathology, Albert Einstein College of Medicine and Bronx Municipal Hospital Center.

Arch Intern Med. 1964;114(1):95-102. doi:10.1001/archinte.1964.03860070141018

The first description of human toxoplasmosis has been credited 1 to Janku, who in 1923 described an infant who had chorioretinitis and hydrocephalus. Pinkerton and Weinman 2 described in 1940 the first adult patient with toxoplasmosis recorded in the United States. Since then an increasing number of cases of toxoplasmosis in infants, juveniles, and adults have been added to the literature. Acquired toxoplasmosis in the adult presents most often with lymphadenopathy and pursues a self-limited course with eventual recovery.1 Few examples of acquired toxoplasmosis with a fatal outcome in adults have been reported in the last two decades.

A case of chronic toxoplasmosis in an adult, whose clinical manifestations were those of a severe hemolytic anemia, was recently encountered at postmortem examination. The hematologic complications of acquired toxoplasmosis, in contrast to those of congenital toxoplasmosis, are not well recognized, and a relationship of this infection to anemia and bone

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