[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
August 1964

Needle Biopsy of Bone and Marrow: An Experience With 1,445 Biopsies

Author Affiliations


From the Department of Medicine, School of Medicine, University of Pittsburgh.; Fellow in Hematology (Dr. Ellis); Professor of Medicine (Dr. Jensen); Assistant Professor of Medicine (Dr. Westerman).

Arch Intern Med. 1964;114(2):213-221. doi:10.1001/archinte.1964.03860080063005

Bone marrow examination is a valuable diagnostic aid which is widely used in the study of disease. The relative diagnostic merits and limitations of bone marrow aspiration as compared with bone marrow biopsy have been previously described1 and are generally appreciated. However, until 1958 when McFarland and Dameshek 2 described a simple technique for bone marrow biopsy using a Silverman needle, relatively few biopsies were done because of the attendant requisites of a surgical procedure. In 1959, Brody and Finch 3 reported their experience with 20 Silverman needle biopsies in patients in whom inadequate aspirates or dry taps had been obtained and concluded that the dry tap was the principal indication for the needle biopsy. In 1960, Westerman et al4 described the specific diagnostic usefulness of 130 Silverman needle biopsies, and Pearson et al 5 demonstrated the adequacy of the biopsy technique in children. After these studies, Ley