Hereditary hemorrhagic telangiectasia (Osler's disease) is a well-defined entity transmitted as a simple mendelian dominant. It is characterized by typical vascular lesions of the skin and mucous membranes, and by hemorrhagic manifestations—most commonly epistaxis—appearing in late adult life. A classical and accurate description of this disease was written by Osier1; subsequent pathologic and clinical studies have been summarized in a thorough review by Bean.2 In the last 15 years the occurrence of pulmonary arteriovenous shunts,3 hemangiomas of the liver associated with portal fibrosis,4 and reports of aneurysms of the splenic5 and hepatic 2 arteries have led to the recognition that these patients may have a generalized derangement in blood vessel structure and function. The following report deals with the presence of an aortic aneurysm in a patient with this disease. Such an occurrence has not been previously recorded.
Report of Case
A 77-year-old woman of Norwegian origin was admitted to
MUGGIA FM. Osler's Disease With an Aortic Arch Aneurysm: Report of a Case. Arch Intern Med. 1964;114(2):307–310. doi:10.1001/archinte.1964.03860080157018
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