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September 1964

Xanthomatous Biliary Cirrhosis Treated With Cholestyramine: Report of a Case

Author Affiliations


From the Department of Dermatology, Stobhill General Hospital.

Arch Intern Med. 1964;114(3):321-328. doi:10.1001/archinte.1964.03860090055002

Xanthomatous biliary cirrhosis (XBC) is a rare disease, and its treatment has been unsatisfactory. Lately, however, a new hypocholesteremic agent, cholestyramine, a quaternary ammonium anionic exchange resin with a specific affinity for bile acids, has been tried with promising results.32 This agent has also been tried with success as an antipruritic in cases of chronic obstructive jaundice.15,6,7

Our case of XBC was treated unsuccessfully with a corn-oil diet two years ago, and full details were reported at that time.10 Since then we have obtained a supply of the resin, cholestyramine, and would like to report our observations on its use.

Methods  Specimens of blood withdrawn after an overnight fast were centri fuged, and the separated serum was stored at —20 C unless the assays were begun without delay. Prothrombin time was measured by the Quick one-stage method. Fast excretion test was carried out as described by Frazer (1960).12 Lipid fractions