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September 1964

Chronic Lymphocytic Leukemia With Hemolytic Anemia: A Long Survival

Arch Intern Med. 1964;114(3):444-448. doi:10.1001/archinte.1964.03860090178022

Introduction  Chronic lymphocytic leukemia is known for its varied course, from a relatively benign process to a much more malignant one, associated with a high morbidity. The association of chronic lymphocytic leukemia with acute hemolytic anemia in itself would not warrant a report. But the case to be presented is a most unusual one in that there appears to be a complete and a sustained clinical and hematological re- covery after one year of treatment with adrenocorticotropic hormone.

Report of Case  A 56-year-old white married male (No. 34902) was first admitted to Memorial Center on May 28, 1954, with a history of progressive weakness and fatigue of about six months' duration. Shortness of breath with exertion, palpitation, and leg cramps began to appear four to six weeks prior to admission. There was no history of gross bleeding. A weight loss of 10 lb (4.5 kg) was noted over the year

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