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October 1964

Gastric Secretory Activity With Reference to HC1Clinical Interpretations

Arch Intern Med. 1964;114(4):508-520. doi:10.1001/archinte.1964.03860100090010

Introduction  Opinions vary as to the usefulness of gastric analysis; attributable, in part, to differing techniques, yielding variable results, which are difficult to interpret clinically and, in part, to undervaluation of gastric secretory data acquired properly. This paper reviews briefly some recent developments in knowledge of gastric secretion and its measurement, in relation to their clinical applicability.

Constituents of Gastric Secretion  Gastric secretion is unique in its acidity and its digestive properties. The capacity of the parietal cells to elaborate large quantities of hydrochloric acid without injury, and the resistance of the gastric wall to the acidpepsin content, under normal conditions, remain among the more challenging biological problems in man.

Hydrochloric Acid.  —Hydrochloric acid is secreted by the parietal cells, the process apparently involving oxidative phosphorylation via aerobic glycolysis.1 A constant concentration of hydrogen ion is produced initially, estimated at approximately 160 mEq/liter2; this concentration then is diluted

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