In the course of the past 15 years, dialysis has been employed with increasing frequency for treating patients with chronic renal failure. Acknowledged indications for dialysis include rapid deterioration caused by an intercurrent illness or acute exacerbation of the underlying disease, and relief of azotemia before surgery.1-3 More recently, dialysis has been employed in the management of patients with end-stage kidney disease.4,5 A significant prolongation of life has been obtained in a few patients by a program of "periodic" dialyses performed at intervals of three to seven days.6 Unfortunately, this type of therapy has so many drawbacks and is so costly that it can be made available to a very small minority of carefully selected patients.
An alternate approach to the therapy of advanced, chronic renal failure is to employ dialysis on an "intermittent" basis, whenever medical management alone fails to produce relief of uremia. The present
SMITH RD, SIMON NM, del GRECO F. Intermittent Dialysis in Chronic Uremia. Arch Intern Med. 1964;114(5):610–615. doi:10.1001/archinte.1964.03860110080005
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