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November 1964

?-Type I Myeloma and Xanthomatosis

Author Affiliations


Associate Professor of Medicine (Dr. Levin); Research Fellow (Dr. Aboumrad); Research Assistant Professor (Dr. Ritzmann); Practicing Physician (Dr. Brantly).

From the Department of Medicine, Hematology Research Laboratory, the Department of Pathology, University of Texas Medical Branch, Galveston, Tex, and Odessa, Tex.

Arch Intern Med. 1964;114(5):688-693. doi:10.1001/archinte.1964.03860110158019

In multiple myeloma the concentration of serum lipoproteins is usually decreased.1,10 In a few patients, lipoproteins are markedly increased.11-16 Franklin et al27 have examined two patients with γ-type myeloma of type I specificity associated with hyperlipoidemia. In these, elevation of cholesterol and/ or lipoproteins due to the fortuitous occurrence of thyroid or renal diseases 25 or diabetes mellitus must be considered. Recently, several cases of myeloma associated with xanthomatosis have been reported.1,17-23 We have had under observation a man with xanthomatous myeloma, splenomegaly, absence of osteolytic lesions, and the presence of an "M"-protein in the γglobulin range on serum paper electrophoresis.

Attempts to correlate the various immunological types of myeloma (γ-, γ2-A, and γmicron-, or Bence Jones)1,2 with clinical manifestations suggested the existence of a subtype of γ2-A-myeloma associated with xanthomatosis.1,3 Xanthomatous myeloma, however, is not specifically associated with abnormal β2-A-globulin as demonstrated by the following patient.

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