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November 1964

The Chemistry and Therapy of Disorders of Voluntary Muscles.

Arch Intern Med. 1964;114(5):712. doi:10.1001/archinte.1964.03860110182033

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This small book provides a pleasantly readable summary of much that is recent in the realm of skeletal muscle disorders. The subject matter has been arranged in a manner that is in keeping with a current classification of these diseases. Such a grouping of topics provides the general medical reader with a helpful framework for viewing this area of human illness.

The introductory chapter, by G. R. Williams, represents a brief but especially clear outline of muscle biochemistry. Much of the material discussed is being investigated actively; accordindly definitive pronunciations are not possible. A clear statement regarding the studies and paths being followed is well sketched. Among the topics considered is the nature of mechanochemical coupling. The significance of nonesterified fatty acids, as well as carbohydrates, as a fuel source for human muscle is mentioned. All of the discussions are necessarily abbreviated, but they are accompanied by helpful bibliography. The

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