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December 1964

Diffuse Glomerular Metastases From Hypernephroma

Arch Intern Med. 1964;114(6):803-805. doi:10.1001/archinte.1964.03860120115013

Many of the bizarre symptoms, laboratory findings, and metastatic behavior of hypernephroma are well known.1,2 This report is stimulated by our experience with a patient having a hypernephroma which metastasized to the glomeruli of the opposite kidney and caused renal failure. A review of recent literature did not reveal a previous description of this unusual metastatic spread.

Report of Case  A 48-year-old Caucasian man (No. 05-30-73) was referred to this hospital for consideration of extracorporeal hemodialysis.Six weeks before admission he developed a midlumbar backache. This did not respond to rest, analgesics, and physical therapy. Physical examination was unrevealing save for tenderness in the left lumbar area. The hematocrit was 39%, and the blood urea nitrogen (BUN) was 47 mg%. Urinalysis was normal on three occasions. Intravenous urogram did not demonstrate the calyceal systems. Retrograde pyelograms revealed bilateral calyceal deformity suggestive of polycystic disease. The left kidney was much

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