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December 1964

Perforation of Small Bowel in Amyloidosis: Includes Review of the Literature

Author Affiliations


From the Department of Medicine, University of Cincinnati, College of Medicine, and Cincinnati General Hospital.; Senior Medical Resident (Dr. Akbarian), and Cardiology Fellow (Dr. Fenton), Department of Medicine, Cincinnati General Hospital, University of Cincinnati, College of Medicine.

Arch Intern Med. 1964;114(6):815-821. doi:10.1001/archinte.1964.03860120127016

Although amyloidosis is a protean disease with many chronic manifestations, it may rarely present suddenly as a catastrophic event, due to rupture of an amyloid-infiltrated organ.

The purpose of this paper is to report a case of perforation of the small bowel in amyloidosis and to review the English literature regarding the sudden complications which have been observed in the course of this disease. To our knowledge this complication of amyloidosis has not been previously reported.

Report of Case  A 61-year-old white man (C.G.H. No. 417046) was admitted to the Cincinnati General Hospital on May 23, 1963, because of weight loss and abdominal pain. At age 50 he had a perforated peptic ulcer which was repaired at another hospital. Subsequently he was asymptomatic until six months prior to admission when he noted a recurrence of "ulcer pains" relieved by food and alkali. After this an 80 lb (36.3 kg) weight

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