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January 1965

Hepatoma With Dysproteinemia and Erythrocythemia

Author Affiliations


USPHS Postdoctoral Research Fellow in Hematology (Dr. Libre), Senior Resident in Medicine (Dr. Rodilosso), Department of Medicine, Veterans Administration Hospital.

Arch Intern Med. 1965;115(1):48-52. doi:10.1001/archinte.1965.03860130050008

PRIMARY carcinoma of the liver has been associated with a variety of "paraneoplastic" syndromes, suggesting various metabolic, endocrine, hematologic, vascular, and osseous diseases.1 The reported association of hepatoma and dysproteinemia has been rather infrequent. In 1962 Viallet et al reported a single case and were able to collect only three additional cases from the literature.2-5 On the other hand, secondary polycythemia in association with hepatoma has been reported with greater frequency.6-11 The observation of a patient with hepatoma showing both dysproteinemia and erythrocythemia forms the basis for this report. The present patient, additionally, showed significant plasmacytic reaction in the tumor as well as in the bone marrow.

Report of Case  A 58-year-old Negro laborer was first admitted to the Veterans Administration Hospital, Washington, DC, on July 5, 1960, because of weakness of the left arm. He had sustained a fall four months previously, bruising the deltoid region