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January 1965

The Zymogram in Clinical Medicine.

Arch Intern Med. 1965;115(1):119. doi:10.1001/archinte.1965.03860130121045

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The machinery of life is built of enzymes patterned in templates of nuclear material. Enzymes are complex polymers and they come in a variety of sizes, shapes, and shades. An enzyme which has a specific chemical catalytic function can be separated into a number of components in an electrical field, especially if the separation is carried out in starch gel or some other medium which imposes a pore size. Serum contains many enzymes which leak from normal or diseased organs. Clinical medical practitioners have learned to rely upon the activity of glutamic oxaloacetic transaminase as an index of the severity of myocardial infarction and as an index of the activity of hepatitis. The temptation posed by enzyme electrophoresis extends into medical diagnosis and medical genetics because of the relationships of its patterns to variations in the molecular structure of normal and abnormal enzymes. Now an enzyme can be studied by

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